风险和不确定性包括但不限于, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of the recent global outbreak of novel coronavirus disease (新型冠状病毒肺炎); the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new 产品 and patents attained by competitors; challenges inherent in new product 发展, including obtaining regulatory approval; the company’s ability to accurately predict 未来 market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company’s patents and other protections for innovative 产品; and the exposure to litigation, 包括专利诉讼, 和/或监管行动.